As of my last knowledge update in January 2022, popular nightclubs in Malaysia might have changed. However, as of then, some well-known nightclubs included:
1. Zouk Club, Kuala Lumpur: Renowned for its vibrant atmosphere and top-notch DJs, offering different themed rooms.
2. PLAY Club, Kuala Lumpur: Located in The Roof, it features a stylish ambiance and hosts international DJs.
3. Pisco Bar, Kuala Lumpur: A trendy spot with a mix of live music, DJs, and a great selection of cocktails.
4. KYO, Kuala Lumpur: Known for its electronic music and a lively atmosphere, attracting a younger crowd.
5. Prime Touch Luxury, Penang: Offers an upscale clubbing experience with a variety of music genres.
6. Soju Sunway, Selangor: A popular spot with various themed nights and a diverse music selection.
Remember that the popularity of nightclubs can change, and it's advisable to check for the latest information or local recommendations for the current best nightclubs in Malaysia. Additionally, due to potential changes in the nightlife scene, it's a good idea to verify this information for the most up-to-date recommendations.